Dna relationship with chromosomes

Genes and Chromosomes - Fundamentals - MSD Manual Consumer Version

dna relationship with chromosomes

Genes and Chromosomes and Fundamentals - Learn about from the MSD Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a. How do chromosomes, DNA and genes all fit together? We can use the analogy of a city to better understand the relationship between DNA molecules. Your genes are part of what makes you the person you are. You are different from everyone alive now and everyone who has ever lived. DNA. But your genes.

The body produces thousands of different enzymes. Thus, the entire structure and function of the body is governed by the types and amounts of proteins the body synthesizes. Protein synthesis is controlled by genes, which are contained on chromosomes. The phenotype typically differs somewhat from the genotype because not all the instructions in the genotype may be carried out or expressed. Whether and how a gene is expressed is determined not only by the genotype but also by the environment including illnesses and diet and other factors, some of which are unknown.

Genes Humans have about 20, to 23, genes. DNA contains the code, or blueprint, used to synthesize a protein. Genes vary in size, depending on the sizes of the proteins for which they code.

Each DNA molecule is a long double helix that resembles a spiral staircase containing millions of steps. The steps of the staircase consist of pairs of four types of molecules called bases nucleotides.

In each step, the base adenine A is paired with the base thymine Tor the base guanine G is paired with the base cytosine C. Except for certain cells for example, sperm and egg cells and red blood cellsthe cell nucleus contains 23 pairs of chromosomes. A chromosome contains many genes. A gene is a segment of DNA that provides the code to construct a protein. The DNA molecule is a long, coiled double helix that resembles a spiral staircase.

The relationship between nucleus, chromosome, dna, genes, and alleles

In it, two strands, composed of sugar deoxyribose and phosphate molecules, are connected by pairs of four molecules called bases, which form the steps of the staircase.

In the steps, adenine is paired with thymine and guanine is paired with cytosine. Each pair of bases is held together by a hydrogen bond. A gene consists of a sequence of bases. Sequences of three bases code for an amino acid amino acids are the building blocks of proteins or other information.

How are DNA, chromosomes, genes, and alleles related?

Synthesizing proteins Proteins are composed of a long chain of amino acids linked together one after another. There are 20 different amino acids that can be used in protein synthesis—some must come from the diet essential amino acidsand some are made by enzymes in the body.

As a chain of amino acids is put together, it folds upon itself to create a complex three-dimensional structure. It is the shape of the folded structure that determines its function in the body.

Because the folding is determined by the precise sequence of amino acids, each different sequence results in a different protein. Some proteins such as hemoglobin contain several different folded chains. Instructions for synthesizing proteins are coded within the DNA.

dna relationship with chromosomes

The code is written in triplets. That is, the bases are arranged in groups of three. Particular sequences of three bases in DNA code for specific instructions, such as the addition of one amino acid to a chain. For example, GCT guanine, cytosine, thymine codes for the addition of the amino acid alanine, and GTT guanine, thymine, thymine codes for the addition of the amino acid valine.

How are DNA, chromosomes, genes, and alleles related? | Socratic

Thus, the sequence of amino acids in a protein is determined by the order of triplet base pairs in the gene for that protein on the DNA molecule. The process of turning coded genetic information into a protein involves transcription and translation.

dna relationship with chromosomes

Transcription and translation Transcription is the process in which information coded in DNA is transferred transcribed to ribonucleic acid RNA. When transcription is initiated, part of the DNA double helix splits open and unwinds. The mRNA separates from the DNA, leaves the nucleus, and travels into the cell cytoplasm the part of the cell outside the nucleus—see Figure: There, the mRNA attaches to a ribosome, which is a tiny structure in the cell where protein synthesis occurs.

Each molecule of tRNA brings one amino acid to be incorporated into the growing chain of protein, which is folded into a complex three-dimensional structure under the influence of nearby molecules called chaperone molecules.

These cells look and act differently and produce very different chemical substances. However, every cell is the descendant of a single fertilized egg cell and as such contains essentially the same DNA. Cells acquire their very different appearances and functions because different genes are expressed in different cells and at different times in the same cell.

The information about when a gene should be expressed is also coded in the DNA. Gene expression depends on the type of tissue, the age of the person, the presence of specific chemical signals, and numerous other factors and mechanisms. Knowledge of these other factors and mechanisms that control gene expression is growing rapidly, but many of these factors and mechanisms are still poorly understood. The mechanisms by which genes control each other are very complicated.

Genes have markers to indicate where transcription should begin and end.

dna relationship with chromosomes

Various chemical substances such as histones in and around the DNA block or permit transcription. Replication Cells reproduce by splitting in two.

dna relationship with chromosomes

Because each new cell requires a complete set of DNA molecules, the DNA molecules in the original cell must reproduce replicate themselves during cell division. Replication happens in a manner similar to transcription, except that the entire double-strand DNA molecule unwinds and splits in two. After splitting, bases on each strand bind to complementary bases A with T, and G with C floating nearby.

When this process is complete, two identical double-strand DNA molecules exist. There are also chemical mechanisms to repair DNA that was not copied properly. However, because of the billions of base pairs involved in, and the complexity of, the protein synthesis process, mistakes can happen. Such mistakes can occur for numerous reasons including exposure to radiation, drugs, or viruses or for no apparent reason.

Minor variations in DNA are very common and occur in most people. Most variations do not affect subsequent copies of the gene.

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Mistakes that are duplicated in subsequent copies are called mutations. Inherited mutations are those that may be passed on to offspring. Mutations can be inherited only when they affect the reproductive cells sperm or egg. Mutations that do not affect reproductive cells affect the descendants of the mutated cell for example, becoming a cancer but are not passed on to offspring. Mutations may be unique to an individual or family, and most mutations are rare.

Mutations may involve small or large segments of DNA.

Cell division - AQA

Depending on its size and location, the mutation may have no apparent effect or it may alter the amino acid sequence in a protein or decrease the amount of protein produced. If the protein has a different amino acid sequence, it may function differently or not at all. An absent or nonfunctioning protein is often harmful or fatal. For example, in phenylketonuriaa mutation results in the deficiency or absence of the enzyme phenylalanine hydroxylase. This deficiency allows the amino acid phenylalanine absorbed from the diet to accumulate in the body, ultimately causing severe intellectual disability.

In rare cases, a mutation introduces a change that is advantageous. For example, in the case of the sickle cell gene, when a person inherits two copies of the abnormal gene, the person will develop sickle cell disease. However, when a person inherits only one copy of the sickle cell gene called a carrierthe person develops some protection against malaria a blood infection.

Although the protection against malaria can help a carrier survive, sickle cell disease in a person who has two copies of the gene causes symptoms and complications that may shorten life span.

The DNA molecule has two important properties. It can make copies of itself. If you pull the two strands apart, each can be used to make the other one and a new DNA molecule. It can carry information. The order of the bases along a strand is a code - a code for making proteins. Genes A gene is a length of DNA that codes for a specific protein.

DNA, genes and chromosomes — University of Leicester

So, for example, one gene will code for the protein insulin, which is important role in helping your body to control the amount of sugar in your blood.

Genes are the basic unit of genetics. Human beings have 20, to 25, genes. These genes account for only about 3 per cent of our DNA. The function of the remaining 97 per cent is still not clear, although scientists think it may have something to do with controlling the genes. Chromosomes If you took the DNA from all the cells in your body and lined it up, end to end, it would form a strand million miles long but very, very thin!

To store this important material, DNA molecules are tightly packed around proteins called histones to make structures called chromosomes. The packaging of DNA into chromosomes Human beings have 23 pairs of chromosomes in every cell, which makes 46 chromosomes in total.

A photograph of a person's chromosomes, arranged according to size, is called a karyotype. The sex chromosomes determine whether you are a boy XY or a girl XX.

The other chromosomes are called autosomes. The karyotype of a male human being The largest chromosome, chromosome 1, contains about genes.